NDLI: Long Noncoding RNA MALAT-1 Can Predict Poor Prognosis: A Meta-Analysis.

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Long Noncoding RNA MALAT-1 Can Predict Poor Prognosis: A Meta-Analysis.

Content Provider	Europe PMC
Author	Tang, Ruixue Jiang, Mengtong Liang, Lu Xiong, Dandan Dang, Yiwu Chen, Gang
Copyright Year	2016
Abstract	BackgroundMALAT-1 is a highly conserved nuclear long non-coding RNA (lncRNA). The overexpression of MALAT-1 has been reported in several types of cancers. This meta-analysis was conducted to further investigate its potential role as a prognostic indicator in various cancers.Material/MethodsThe meta-analysis was performed by use of systematic search terms in 13 databases for qualified papers on prognosis in cancer from inception to June 30, 2015. The combined hazard ratios (HRs) with 95% confidence interval (95% CI) were computed to demonstrate the effect of MALAT-1 on prognosis of cancers.ResultsA total of 590 papers were initially identified, and 17 studies were finally included in this paper. Meta-analysis was accomplished with a total of 1626 patients. Combined HRs and 95% CI were calculated by fixed-effects or random-effects models. The quality assessment of included studies was performed by the Newcastle-Ottawa scale (NOS). High expression of MALAT-1 was found to be an indicator of poor prognosis in overall survival (OS) (HR=1.84, 95% CI: 1.27–2.67) and disease-free survival (DFS) (HR=2.37, 95% CI: 1.55–3.62). In subgroups, the associations between MALAT-1 and survival were also apparent, for instance, in country subgroup: China (HR=1.85, 95% CI: 1.14–2.99).ConclusionsThe overexpression of MALAT-1 may be a potential prognostic indicator for various human cancers.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	22
PubMed Central reference number	PMC4737057
PubMed reference number	26821178
e-ISSN	16433750
DOI	10.12659/msm.895171
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2016-01-28
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License © Med Sci Monit, 2016
Subject Keyword	Genes, Neoplasm Meta-Analysis Prognosis RNA, Long Noncoding Survival
Content Type	Text
Resource Type	Article
Subject	Medicine

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