Frequency and pattern of noninfectious adverse transfusion reactions at a tertiary care hospital in Korea.

Content Provider	Europe PMC
Author	Cho, Jooyoung Choi, Seung Jun Kim, Sinyoung Alghamdi, Essam Kim, Hyun Ok
Copyright Year	2016
Abstract	BackgroundAlthough transfusion is a paramount life-saving therapy, there are multiple potential significant risks. Therefore, all adverse transfusion reaction (ATR) episodes require close monitoring. Using the computerized reporting system, we assessed the frequency and pattern of non-infectious ATRs.MethodsWe analyzed two-year transfusion data from electronic medical records retrospectively. From March 2013 to February 2015, 364,569 units of blood were transfused. Of them, 334,582 (91.8%) records were identified from electronic nursing records. For the confirmation of ATRs by blood bank physicians, patients' electronic medical records were further evaluated.ResultsAccording to the nursing records, the frequency of all possible transfusion-related events was 3.1%. After the blood bank physicians' review, the frequency was found to be 1.2%. The overall frequency of febrile non-hemolytic transfusion reactions (FNHTRs) to red blood cells (RBCs), platelet (PLT) components, and fresh frozen plasmas (FFPs) were 0.9%, 0.3%, and 0.2%, respectively, and allergic reactions represented 0.3% (RBCs), 0.9% (PLTs), and 0.9% (FFPs), respectively. The pre-storage leukocyte reduction significantly decreased the frequency of FNHTRs during the transfusion of RBCs (P<0.01) or PLTs (P≒0.01).ConclusionsThe frequency of FNHTRs, allergic reactions, and "no reactions" were 22.0%, 17.0%, and 60.7%, respectively. Leukocyte-reduction was associated with a lower rate of FNHTRs, but not with that of allergic reactions. The development of an effective electronic reporting system of ATRs is important in quantifying transfusion-related adverse events. This type of reporting system can also accurately identify the underlying problems and risk factors to further the quality of transfusion care for patients.
ISSN	22343806
Journal	Annals of Laboratory Medicine
Volume Number	36
PubMed Central reference number	PMC4697341
Issue Number	1
PubMed reference number	26522757
e-ISSN	22343814
DOI	10.3343/alm.2016.36.1.36
Language	English
Publisher	The Korean Society for Laboratory Medicine
Publisher Date	2016-01-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © The Korean Society for Laboratory Medicine.
Subject Keyword	Adverse transfusion reaction Febrile non-hemolytic transfusion reaction Allergic reaction Transfusion reporting system
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry