Cardioprotective effect of aqueous extract of Chichorium intybus on ischemia-reperfusion injury in isolated rat heart.

Content Provider	Europe PMC
Author	Sadeghi, Najmeh Dianat, Mahin Badavi, Mohammad Malekzadeh, Ahad
Abstract	Objective: Several studies have shown that Chichorium intybus (C. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. Contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty.The aim of the present study was to investigate the effect of aqueous extract of C. intybus on ischemia- reperfusion injury in isolated rat heart.Materials and Methods:The animals were divided into four groups (Sham, Control, 1 mg/ml and 3 mg/ml of extract) of 8 rats. The aorta was cannulated, and then the heart was mounted on a Langendorff apparatus. Next, a balloon was inserted into the left ventricle (LV) and peak positive value of time derivate of LV pressure (+dp/dt), coronary flow (CF), and left ventricular systolic pressure (LVSP) in pre-ischemia and reperfusion period were calculated by a Power Lab system. All groups underwent a 30-minute global ischemia followed by a 60-minute reperfusion.Results:The results showed that heart rate (HR), coronary flow, and left ventricular developed pressure (LVDP) and rate of pressure product (RPP) significantly decreased in the control group during reperfusion, while these values in the groups receiving the extract (3mg/ml) improved significantly during reperfusion (p<0.001). Conclusion:It seems that flavonoid compounds of aqueous extract of C. intybus reduce ischemia - reperfusion injuries, suggesting its protective effect on heart function after ischemia.
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ISSN	22287930
Journal	Avicenna Journal of Phytomedicine [Avicenna J Phytomed]
Volume Number	5
PubMed Central reference number	PMC4678502
Issue Number	6
PubMed reference number	26693414
e-ISSN	22287949
Language	English
Publisher	Mashhad University of Medical Sciences
Publisher Date	2015-11-01
Publisher Place	Mashhad, Iran
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Subject Keyword	Chichorium intybus L. Ischemia-Reperfusion Heart Contractility Rat
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Complementary and Alternative Medicine