NDLI: Genetic Polymorphisms Analysis of Pharmacogenomic VIP Variants in Miao Ethnic Group of Southwest China.

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Genetic Polymorphisms Analysis of Pharmacogenomic VIP Variants in Miao Ethnic Group of Southwest China.

Content Provider	Europe PMC
Author	Jin, Tianbo Aikemu, Ainiwaer Zhang, Mingxia Geng, Tingting Feng, Tian Kang, Longli Luo, Manlin
Copyright Year	2015
Abstract	BackgroundGenetic polymorphisms have a potential clinical role in determining both inter-individual and inter-ethnic differences in drug efficacy, but we have not found any pharmacogenomics information regarding minorities, such as the Miao ethnic group. Our study aimed to screen numbers of the Miao ethnic group for genotype frequencies of VIP variants and to determine differences between the Miao and other human populations worldwide.Material/MethodsIn this study, we genotyped 66 Very Important Pharmacogene (VIP) variants selected from PharmGKB in 98 unrelated, healthy Miao individuals from the Guizhou province and compared our data with 12 other populations, including 11 populations from the HapMap data set and Xi’an Han Chinese.ResultsUsing the χ2 test, we found that the allele frequencies of the VDR rs1544410 and VKORC1 (rs9934438) variants in the Miao population are quite different from that in other ethnic groups. Furthermore, we found that genotype frequencies of rs1801133 (MTHFR) in the 13 selected populations are significantly different. Population structure and F-statistics (Fst) analysis show that the genetic background of the Miao is relatively close to that of Chinese in metropolitan Denver, CO, USA (CHD).ConclusionsOur results help complete the information provided by the pharmacogenomics database of the Miao ethnic group and provide a theoretical basis for safer drug administration, which may be useful for diagnosing and treating diseases in this population.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	21
PubMed Central reference number	PMC4672675
PubMed reference number	26632549
e-ISSN	16433750
DOI	10.12659/msm.895191
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2015-12-03
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License © Med Sci Monit, 2015
Subject Keyword	Ethnic Groups Genetic Counseling Genomic Structural Variation
Content Type	Text
Resource Type	Article
Subject	Medicine

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