NDLI: Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val.

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Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val.

Content Provider	Europe PMC
Author	Hou, Yan Lu, Chuan-Li Zeng, Qiao-Hui Jiang, Jian-Guo
Copyright Year	2015
Abstract	Curcuma phaeocaulis Val. is used in Chinese Pharmacopoeia as health food and folk medicine for removing blood stasis, alleviating pain and tumor therapy. This research was aimed to explore and compare three main bioactivities including anti-oxidant, antitumor and anti-inflammatory activities between the ethanol extract of C. Phaeocaulis and its fractions using different in vitro models. Firstly, 70 % ethanol was used to extract C. Phaeocaulis, and then the crude extract was re-extracted, resulting in petroleum ether (EZ-PE), ethyl acetate (EZ-EA), and water fractions (EZ-W), respectively, and then a series of index was detected. Results showed that all the extracts had medium DPPH radical scavenging activity when the concentration was 200 μg/ml and their DPPH radical scavenging activity was in a concentration-dependent manner. The extracts except ethanol extract of C. Phaeocaulis had almost no cytotoxicity to the survival of RAW264.7 cell when the concentration reached 80 μg/ml, and all of them had medium inhibitory effect on nitrite release. Extracts of C. Phaeocaulis had medium intensity antitumor activity, EZ-PE and EZ-EA fractions significantly inhibited the proliferation of four tumor cells (SMMC-7721 cell lines, HepG-2 cell lines, A549 cell lines and Hela cell lines). C. Phaeocaulis had antioxidant and anti-inflammatory activities, which did not carry out centralized phenomenon when re-extracted. EZ-PE and EZ-EA were active antitumor sites of C. Phaeocaulis.
Journal	EXCLI Journal
Volume Number	14
PubMed Central reference number	PMC4669906
PubMed reference number	26648822
e-ISSN	16112156
DOI	10.17179/excli2015-231
Language	English
Publisher	Leibniz Research Centre for Working Environment and Human Factors
Publisher Date	2015-06-12
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited. Copyright © 2015 Hou et al.
Subject Keyword	Curcuma phaeocaulis Val. anti-oxidant anti-tumor anti-inflammatory
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Animal Science and Zoology Molecular Medicine

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