NDLI: Clinical significance of galectin-7 in vulvar squamous cell carcinoma.

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Clinical significance of galectin-7 in vulvar squamous cell carcinoma.

Content Provider	Europe PMC
Author	JIANG, YING TIAN, RUOYANG YU, SHUANG ZHAO, YI CHEN, YANG LI, HUI QIAO, YING WU, XIN
Copyright Year	2015
Abstract	The present study reports the role of galectin-7 (Gal-7) expression in vulvar squamous cell carcinoma (VSCC) and its correlation with clinicopathological variables. Gal-7 expression was immunohistochemically detected in the paraffin-embedded sections of 20 normal vulvar biopsy samples and 50 VSCC specimens. Expression was also detected in 10 normal vulvar biopsy samples and 10 VSCC specimens by western blotting. In addition, the methylation status of the promoter of the Gal-7 gene was determined in 30 VSCC specimens and 20 samples of normal vulvar tissue by methylation-specific polymerase chain reaction. Gal-7 expression was found to be significantly downregulated in the VSCC tissues compared with the normal vulvar tissues (P<0.05). Downregulation of Gal-7 was correlated with advanced clinical stage, poor tumor differentiation and regional lymph node metastasis (P<0.05). Furthermore, methylation of the Gal-7 gene promoter was significantly reduced in the vulvar normal tissues compared with the VSCC tissues (P=0.023), while increased Gal-7 promoter methylation was correlated with advanced clinical stage, poor tumor differentiation and regional lymph node metastasis (P<0.05). There was no association between patient age and Gal-7 promoter methylation. Together, these results suggested that Gal-7 has a negative impact in patients with VSCC, with malignant potential correlating with Gal-7 promoter methylation.
ISSN	17921074
Journal	Oncology Letters
Volume Number	10
PubMed Central reference number	PMC4665703
Issue Number	6
PubMed reference number	26788216
e-ISSN	17921082
DOI	10.3892/ol.2015.3826
Language	English
Publisher	D.A. Spandidos
Publisher Date	2015-10-22
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Jiang et al.
Subject Keyword	vulvar squamous cell carcinoma galectin-7 methylation immunohistochemistry western blotting
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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