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Bio-imaging and Photodynamic Therapy with Tetra Sulphonatophenyl Porphyrin (TSPP)-TiO2 Nanowhiskers: New Approaches in Rheumatoid Arthritis Theranostics.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhao, Chunqiu Ur Rehman, Fawad Yang, Yanlong Li, Xiaoqi Zhang, Dong Jiang, Hui Selke, Matthias Wang, Xuemei Liu, Chongyang |
| Copyright Year | 2015 |
| Abstract | Since Rheumatoid arthritis (RA) is one of the major human joint diseases with unknown etiology, the early diagnosis and treatment of RA remains a challenge. In this contribution we have explored the possibility to utilize novel nanocomposites of tetera suplhonatophenyl porphyrin (TSPP) with titanium dioxide (TiO2) nanowhiskers (TP) as effective bio-imaging and photodynamic therapeutic (PDT) agent for RA theranostics. Our observations demonstrate that TP solution PDT have an ameliorating effect on the RA by decreasing significantly the IL-17 and TNF-α level in blood serum and fluorescent imaging could enable us to diagnose the disease in subclinical stages and bio-mark the RA insulted joint. |
| Journal | Scientific Reports [Sci Rep] |
| Volume Number | 5 |
| DOI | 10.1038/srep11518 |
| PubMed Central reference number | PMC4648397 |
| PubMed reference number | 26153895 |
| e-ISSN | 20452322 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2015-07-08 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |