Loading...
Please wait, while we are loading the content...
New prospects for a preventive HIV-1 vaccine.
| Content Provider | Europe PMC |
|---|---|
| Author | Brown, Jeffrey Excler, Jean-Louis Kim, Jerome H |
| Abstract | AbstractThe immune correlates of risk analysis and recent non-human primate (NHP) challenge studies have generated hypotheses that suggest HIV-1 envelope may be essential and, perhaps, sufficient to induce protective antibody responses against HIV-1 acquisition at the mucosal entry. New prime-boost mosaic and conserved-sequence, together with replicating vector immunisation strategies aiming at inducing immune responses or greater breadth, as well as the development of immunogens inducing broadly neutralising antibodies and mucosal responses, should be actively pursued and tested in humans. Whether the immune correlates of risk identified in RV144 can be extended to other vaccines, other populations, or different modes and intensity of transmission, and against increasing HIV-1 genetic diversity, remains to be demonstrated. Although NHP challenge studies may guide vaccine development, human efficacy trials remain key for answering the critical questions leading to the development of a global HIV-1 vaccine for licensure. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4625840&blobtype=pdf |
| ISSN | 20556640 |
| Journal | Journal of Virus Eradication [J Virus Erad] |
| Volume Number | 1 |
| PubMed Central reference number | PMC4625840 |
| Issue Number | 2 |
| PubMed reference number | 26523292 |
| e-ISSN | 20556659 |
| Language | English |
| Publisher | Mediscript Ltd |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Rights License | This is an open access article published under the terms of a Creative Commons License. © 2015 The Authors. Journal of Virus Eradication published by Mediscript Ltd |
| Subject Keyword | HIV vaccine HIV prevention clinical trials efficacy immune correlates |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology Public Health, Environmental and Occupational Health Immunology Epidemiology |
