Salivary antioxidants of male athletes after aerobic exercise and garlic supplementation on: A randomized, double blind, placebo-controlled study.

Content Provider	Europe PMC
Author	Damirchi, Arsalan Saati Zareei, Alireza Sariri, Reyhaneh
Copyright Year	2015
Abstract	Purpose Production of reactive oxygen species and reactive nitrogen species is a natural biological event in metabolism. However, the presence of antioxidants can highly reduce the negative effect of free radicals. Thus, the efficiency of antioxidant system in the physiology of exercise is very important. Design Considering the known antioxidant capacity of garlic, the purpose of this study was to evaluate the effect on combining 14 days aerobic exercise till exhaustion with garlic extract supplementation on the antioxidant capacity of saliva. Methods Sixteen young men volunteered to participate in this randomized, double blind, placebo-controlled study and were randomly placed into two groups, placebo (Group I) and garlic extract (Group II). The participants performed exhaustive aerobic exercise on a treadmill before and after supplementation. Their unstimulated salivary samples were collected before, immediately after, and 1 h after the activity. The antioxidant activity in terms of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) was then measured in the collected samples using their specific substrates. Results A significant increase in salivary antioxidant activity of SOD, POD, and CAT was observed in saliva of the supplement group compared to the placebo group (P ≤ 0.05). Conclusion The findings from this study suggest that increased activity of antioxidant enzymes could possibly decrease exercise-induced oxidative damage in male athletes.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4623234&blobtype=pdf
ISSN	22124268
Volume Number	5
DOI	10.1016/j.jobcr.2015.08.001
PubMed Central reference number	PMC4623234
Issue Number	3
PubMed reference number	26605139
Journal	Journal of Oral Biology and Craniofacial Research [J Oral Biol Craniofac Res]
e-ISSN	22124276
Language	English
Publisher	Elsevier
Publisher Date	2015-08-21
Access Restriction	Open
Rights License	© 2015 Craniofacial Research Foundation. Published by Elsevier B.V. All rights reserved.
Subject Keyword	CAT, catalase EDTA, ethylene diamine tetraacetic acid GTE, green tea extract NBT, nitro blue tetrazolium NF, nuclear factor POD, peroxidase ROS, reactive oxygen species SOD, superoxide dismutase TAC, total antioxidant capacity TNF, tumor necrosis factor TT, tapering training Garlic Free radical Salivary antioxidant capacity Aerobic exercise
Content Type	Text
Resource Type	Article
Subject	Dentistry Otorhinolaryngology