Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder.

Content Provider	Europe PMC
Author	Park, Subin Park, Jong-Eun Yoo, Hee Jeong Kim, Jae-Won Cheong, Jae Hoon Han, Doug Hyun Kim, Yeni Kim, Bung-Nyun
Copyright Year	2015
Abstract	ObjectiveWe tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios.MethodsA total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios.ResultsIn the TDT, we found the over-transmission of the Val allele in children with ADHD (χ2=4.21, p=0.040).ConclusionThese results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
ISSN	17383684
Journal	Psychiatry Investigation
Volume Number	12
PubMed Central reference number	PMC4620316
Issue Number	4
PubMed reference number	26508970
e-ISSN	19763026
DOI	10.4306/pi.2015.12.4.563
Language	English
Publisher	Korean Neuropsychiatric Association
Publisher Date	2015-09-30
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Korean Neuropsychiatric Association
Subject Keyword	Attention-deficit hyperactivity disorder COMT
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health