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Prognostic Value of VEGF in Hepatocellular Carcinoma Patients Treated with Sorafenib: A Meta-Analysis.
| Content Provider | Europe PMC |
|---|---|
| Author | Cao, Guangchao Li, Xiaoyun Qin, Chao Li, Jie |
| Copyright Year | 2015 |
| Abstract | BackgroundHepatocellular carcinoma (HCC) is characterized by rich vascularization in the tumor, and vascular endothelial growth factor (VEGF) plays important roles in vascularization. The results of the roles of VEGF in predicting efficacy of sorafenib in HCC are conflicting. In this meta-analysis, we aimed to investigate the prognostic and predictive value of VEGF in HCC patients receiving sorafenib.Material/MethodsPubMed, Embase, and Cochrane library electronic databases were systematically searched for eligible studies. The baseline characteristics were recorded and overall qualities of the eligible studies were assessed by 2 reviewers independently. VEGF levels and data relevant to efficacy of sorafenib were extracted and used for meta-analysis.ResultsThe comprehensive search yielded 9 studies that evaluated the relationship between VEGF level and clinical outcome in advanced HCC patients treated with sorafenib. Pooled estimates suggested that high level of VEGF was associated with poor overall survival (HR=1.85; 95% CI: 1.24–2.77; P=0.003) and poor progression-free survival (HR=2.09; 95% CI: 1.43–3.05; P<0.01) in HCC. Mutation of VEGF had a favorable effect on hand-foot skin reaction in HCC patients treated with sorafenib (P<0.05).ConclusionsHigh level of VEGF is associated with poor outcomes in HCC patients treated with sorafenib, indicating that VEGF could be used as an indicator of clinical efficacy in patients with HCC. However, more well-designed studies are needed to strengthen our findings. |
| ISSN | 12341010 |
| Journal | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| Volume Number | 21 |
| PubMed Central reference number | PMC4617189 |
| PubMed reference number | 26476711 |
| e-ISSN | 16433750 |
| DOI | 10.12659/msm.894617 |
| Language | English |
| Publisher | International Scientific Literature, Inc. |
| Publisher Date | 2015-10-18 |
| Access Restriction | Open |
| Rights License | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License © Med Sci Monit, 2015 |
| Subject Keyword | Prognosis Carcinoma, Hepatocellular Receptors, Vascular Endothelial Growth Factor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
