Current Treatment of Isolated Locoregional Breast Cancer Recurrences.

Content Provider	Europe PMC
Author	Harms, Wolfgang Geretschläger, Andreas Cescato, Corinne Buess, Martin Köberle, Dieter Asadpour, Branca
Copyright Year	2015
Abstract	Summary Patients with isolated locoregional breast cancer recurrences should be treated with curative intent. Mastectomy is regarded as the standard of care for patients with ipsilateral breast tumor recurrence. In a selected group of patients, partial breast irradiation after second breast-conserving surgery is a viable alternative to mastectomy. If a second breast conservation is performed, additional irradiation should be mandatory, especially in patients who had not been irradiated previously. In case of re-irradiation, the largest experience exists for multi-catheter brachytherapy. Prospective clinical trials are needed to clearly define selection criteria, long-term local control, and toxicity. In patients with resectable locoregional breast cancer recurrences after mastectomy, multi-modal therapy comprising complete resection, radiation therapy in previously unirradiated patients, and systemic therapy results in 5-year disease-free and overall survival rates of 69% and 88%, respectively. In radiation-naive patients with unresectable, isolated locoregional recurrences, radiation therapy is mandatory. In selected patients with previous irradiations and unresectable locoregional recurrences, a second irradiation as part of an individual treatment concept can be applied. The increased risk of severe toxicity should always be weighed up against the potential clinical benefit. A combination therapy with hyperthermia can further improve the treatment results.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4608638&blobtype=pdf
Page Count	7
ISSN	16613791
Volume Number	10
DOI	10.1159/000439151
PubMed Central reference number	PMC4608638
Issue Number	4
PubMed reference number	26600763
Journal	Breast Care
e-ISSN	16613805
Language	English
Publisher	S. Karger Verlag für Medizin und Naturwissenschaften GmbH
Publisher Date	2015-08-21
Publisher Place	Germany
Access Restriction	Open
Rights License	Copyright © 2015 by S. Karger GmbH, Freiburg
Subject Keyword	Ipsilateral breast tumor recurrence Local recurrence breast Locoregional recurrence breast cancer Hyperthermia Radiation therapy Brachytherapy Chest wall recurrence Breast cancer Re-irradiation breast
Content Type	Text
Resource Type	Article
Subject	Surgery Oncology