Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis.

Content Provider	Europe PMC
Author	Lu, Si-Cong Zhong, Jian-Hong Tan, Jun-Tao Tang, Hua-Lin Liu, Xiao-Guang Xiang, Bang-De Li, Le-Qun Peng, Tao
Copyright Year	2015
Abstract	ObjectiveTo investigate the association between cyclo-oxygenase-2 (COX-2) polymorphism and the risk of hepatocellular carcinoma (HCC) development.DesignSystematic review and meta-analysis of COX-2 polymorphism and risk of HCC development among people with or without HCC.Data sourcesEMBASE, PubMed, Public Library of Science, SCOPUS, Web of Knowledge and Chinese National Knowledge Infrastructure were searched for all clinical and experimental case–control studies of COX-2 polymorphism and HCC risk. Studies published up to March 2015 were included.Review methodTen studies were included for data extraction, which were mainly from Asian countries.Results2538 people with HCC and 3714 without HCC were found to satisfy the inclusion criteria and included in the review. The associations of specific genotypes in the eight polymorphic variants of COX-2 and the risk of HCC development were analysed. GG genotype at the A-1195G polymorphism may be associated with a reduced risk of HCC development: the OR across all studies was 0.87 (95% CI 0.75 to 1.02) for the G allele versus the A allele, 0.72 (0.53 to 0.97) for GG versus AA, 0.72 (0.57 to 0.92) for GG versus GA+AA and 1.05 (0.77 to 1.44) for AA versus GA+GG. Similar results were found when the meta-analysis was repeated separately for the Chinese subgroup. However, more reliable data are needed to demonstrate associations between variants in G-765C, T+8473C, A-1290G, G-899C and introns 1, 5 and 6 polymorphisms and the risk of HCC development.ConclusionsOnly the COX-2 A-1195G gene polymorphism may be associated with a decreased risk of HCC development. These conclusions should be verified in further studies.
Journal	BMJ Open
Volume Number	5
PubMed Central reference number	PMC4606424
Issue Number	10
PubMed reference number	26438136
e-ISSN	20446055
DOI	10.1136/bmjopen-2015-008263
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2015-10-05
Publisher Place	London
Access Restriction	Open
Rights License	This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
Subject Keyword	cyclooxygenase-2 hepatocellular carcinoma polymorphism susceptibility
Content Type	Text
Resource Type	Article
Subject	Medicine