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Lower Doses of Bosentan in Combination With Sildenafil Might be Beneficial in Pulmonary Arterial Hypertension.
| Content Provider | Europe PMC |
|---|---|
| Author | Amin, Ahmad Mohamadifar, Arezoo Taghavi, Sepideh Naderi, Nasim Sadeghi, Hosnolah |
| Copyright Year | 2015 |
| Abstract | Background: Endothelin-receptor-antagonist, bosentan, has been found to improve the functional capacity and cardiopulmonary hemodynamics in Pulmonary Arterial Hypertension (PAH). Clinical trials have shown the preferable dosage of 125 mg, twice daily, regarding both efficacy and safety. Objectives: The purpose of this study was to investigate the effects of lower doses of bosentan (62.5 mg, twice daily) in combination with sildenafil on exercise capacity and clinical events, in 41 patients with idiopathic pulmonary hypertension or chronic thromboembolic pulmonary hypertension (CTEPH). Patients and Methods: We assigned 41 patients with PAH (non-reactive idiopathic or non-operable chronic thromboembolic) to receive 62.5 mg of bosentan twice daily as combination therapy and evaluated the New York heart association (NYHA) functional class, 6-minutes-walk-distance (6MWD), time to clinical worsening, echocardiographic indexes and clinical events, for an average of 18.5 ± 9.5 months. Results: No adverse drug reaction was observed during the follow-up. Clinical worsening occurred in six (14%) patients, at least one year after treatment, two of the cases failed to respond to 125 mg, twice daily and died. Eight (19%) remained in FC I_II, but didn’t reach the goal of 380 meters for 6MWD. All other patients reached the treatment goals according to the latest European society of cardiology (ESC) guidelines. Conclusions: We observed acceptable results regarding both efficacy and safety with 62.5 mg of bosentan, twice daily in this group of patients. Further clinical trials investigating PAH with lower dosages of bosentan may be warranted. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4588707&blobtype=pdf |
| ISSN | 22519572 |
| Volume Number | 4 |
| DOI | 10.5812/cardiovascmed.26487v2 |
| PubMed Central reference number | PMC4588707 |
| Issue Number | 3 |
| PubMed reference number | 26436071 |
| Journal | Research in Cardiovascular Medicine [Res Cardiovasc Med] |
| e-ISSN | 22519580 |
| Language | English |
| Publisher | Kowsar |
| Publisher Date | 2015-08-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. Copyright © 2015, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences. |
| Subject Keyword | Pulmonary Hypertension Endothelin Receptor Antagonist Bosentan Chronic Thromboembolic Pulmonary Hypertension |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
