NDLI: Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats.

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Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats.

Content Provider	Europe PMC
Author	Kumar, Arun Kumar, Ranjit Rahman, Mohammad Samuir Iqubal, Mohammad Asif Anand, Gautam Niraj, Pintoo Kumar Ali, Mohammad
Abstract	Objective:The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology.Materials and Methods: In the present study, arsenic in the form of sodium arsenite was administered orally to male Charles Foster rats for 45 days. Thereafter, ethanolic root extract of Withania somnifera was administered for 30 days to observe its ameliorative effect on male reproductive system. Results:The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility. However, after administration of Withania somnifera, there was significant reversal in the parameters denoting that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it.Conclusion: The study concludes that Withania somnifera possesses phytoremedial effect. It is one of the best antidotes against arsenic-induced reproductive toxicity.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4587609&blobtype=pdf
ISSN	22287930
Journal	Avicenna Journal of Phytomedicine [Avicenna J Phytomed]
Volume Number	5
PubMed Central reference number	PMC4587609
Issue Number	4
PubMed reference number	26445714
e-ISSN	22287949
Language	English
Publisher	Mashhad University of Medical Sciences
Publisher Date	2015-07-01
Publisher Place	Mashhad, Iran
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Subject Keyword	Sodium arsenite W. somnifera Rats Testicular toxicity Sperm Count Testosterone
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Complementary and Alternative Medicine

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