Simethicone adjunct to polyethylene glycol improves small bowel capsule endoscopy imaging in non-Crohn's disease patients.

Content Provider	Europe PMC
Author	Papamichael, Konstantinos Karatzas, Pantelis Theodoropoulos, Ioannis Kyriakos, Nikos Archavlis, Emmanuel Mantzaris, Gerasimos J.
Copyright Year	2015
Abstract	BackgroundCurrently, there is no standardized protocol for bowel preparation before small bowel capsule endoscopy (SBCE). This study aimed to investigate the effect of simethicone combined with polyethylene glycol (PEG) on the visualization quality (VQ) of the SBCE in patients with or without known or suspected Crohn’s disease (CD).MethodsThis observational, prospective, single-center study included consecutive patients undergoing a SBCE between 2007 and 2008. Patients received either a standard bowel cleansing preparation of 2 L PEG and 80 mg simethicone orally 12 and 1 h before SBCE respectively (Group A) or only PEG (Group B). VQ, based on scores for luminal bubbles in frames taken from the small intestine, examination completeness, SBCE diagnostic yield, gastric and small bowel transit times were recorded.ResultsOf the 115 patients finally included (Group A, n=56 and Group B, n=59) the cecum was visualized in 103 (89.6%). Simethicone overall improved the VQ in the proximal [OR: 2.43 (95%CI: 1.08-5.45), P=0.032] but not in the distal bowel segment (P=0.064). Nevertheless, this effect was not observed in patients undergoing SBCE for either known or suspected CD.ConclusionSimethicone as an adjunct to PEG for bowel preparation in patients undergoing SBCE significantly improved the VQ in non-CD patients.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4585393&blobtype=pdf
ISSN	11087471
Journal	Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology [Ann Gastroenterol]
Volume Number	28
PubMed Central reference number	PMC4585393
Issue Number	4
PubMed reference number	26423317
e-ISSN	17927463
Language	English
Publisher	Hellenic Society of Gastroenterology
Publisher Date	2015-10-01
Publisher Place	Greece
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Hellenic Society of Gastroenterology
Subject Keyword	Small bowel capsule endoscopy simethicone visualization quality Crohn’s disease
Content Type	Text
Resource Type	Article
Subject	Gastroenterology