NDLI: Antitumor action of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone in hepatocellular carcinoma.

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Antitumor action of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone in hepatocellular carcinoma.

Content Provider	Europe PMC
Author	BO, QI-FU SUN, XIU-MEI LIU, JIN SUI, XIAO-MEI LI, GUI-XIN
Copyright Year	2015
Abstract	The inhibition of apoptosis in cancer cells is the major pathological feature of hepatic carcinoma. Rosiglitazone (RGZ), a ligand for peroxisome proliferator-activated receptor γ (PPAR-γ), has been shown to induce apoptosis in hepatic carcinoma cells. However, the mechanism underlying this effect remains to be elucidated. The present study aimed to investigate the effect of RGZ on cell viability and apoptosis, and its mechanisms in cultured HepG2 cells using MTT assay, flow cytometry and western blotting. The results revealed that treatment with RGZ may attenuate HepG2 cell viability and induce the apoptosis of the cells. The mechanism of RGZ-induced apoptosis involves an increase in the level of activated PPAR-γ (p-PPAR-γ) and a decrease in p85 and Akt expression. In addition, the PPAR-γ antagonist GW9662 suppressed the effect of RGZ in the HepG2 cells. Taken together, the results suggest that RGZ induces the apoptosis of HepG2 cells through the activation of PPAR-γ, suppressing the activation of the PI3K/Akt signaling pathway. Such mechanisms may contribute to the favorable effects of treatment using RGZ in HepG2 cells.
ISSN	17921074
Journal	Oncology Letters
Volume Number	10
PubMed Central reference number	PMC4579902
Issue Number	4
PubMed reference number	26622783
e-ISSN	17921082
DOI	10.3892/ol.2015.3554
Language	English
Publisher	D.A. Spandidos
Publisher Date	2015-07-30
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright: © Bo et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.
Subject Keyword	rosiglitazone peroxisome proliferator-activated receptor γ phosphoinositide 3-kinase/protein kinase B apoptosis proliferation
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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