NDLI: Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population.

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Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population.

Content Provider	Europe PMC
Author	ZHANG, JIANWEI ZHANG, HONGYAN XU, XIN WANG, MINGRONG YU, ZHONGHE
Copyright Year	2015
Abstract	Breast cancer is the most common malignancy in Chinese women. The aim of the present study was to investigate the genetic alterations that occur in breast cancer cells in Chinese women. Comparative genomic hybridization (CGH) analysis was performed on 34 tumors obtained from patients with primary invasive ductal breast carcinoma (IDC). Recurrent genetic alterations in breast cancer include gains on chromosomes 1q (59%), 16p (50%), 17q (44%), 8q (38%), 11q (32%), 20q (32%), 1p (24%), 20p (24%), 19q (21%) and 19p (18%). Losses are common on chromosomes 6q (15%), 8p (12%), 18 (12%), 4q (9%), X (9%) and 17p (9%). In the present study, high-level amplifications were observed on chromosomes 1q32, 8p, 11q13, 17q and 20q. Overall, the chromosomal DNA gains observed were consistent with the changes reported in Caucasian populations. However, the incidence of chromosomal DNA loss was lower in the present study compared with the incidence reported in the literature. The present results demonstrate the pattern of chromosomal imbalances in the invasive ductal breast carcinomas of Chinese females.
ISSN	17921074
Journal	Oncology Letters
Volume Number	10
PubMed Central reference number	PMC4579858
Issue Number	4
PubMed reference number	26622803
e-ISSN	17921082
DOI	10.3892/ol.2015.3608
Language	English
Publisher	D.A. Spandidos
Publisher Date	2015-08-14
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright: © Zhang et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.
Subject Keyword	comparative genomic hybridization ductal breast carcinomas copy number changes
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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