Quantitative comparison of transient elastography (TE), shear wave elastography (SWE) and liver biopsy results of patients with chronic liver disease.

Content Provider	Europe PMC
Author	Kim, Hyun-Jin Lee, Hae-Kag Cho, Jae-Hwan Yang, Han-Jun
Copyright Year	2015
Abstract	[Purpose] The purpose of this study was to carry out a comparitive analysis of hepaticfibrosis results of the liver hardness of patients with chronic liver disease as measuredby elastography (TE), shear wave elastography (SWE), and liver biopsy. [Subjects andMethods] This study was a retrospective analysis of 304 patients who underwent SWE and TEbefore and after liver biopsy, taken from among patients who had been checked for liverfibrosis by liver biopsy between August 2013 and August 2014. We used receiver operatingcharacteristic (ROC) curve to prove the diagnostic significance of liver stiffness, andthen analyzed the sensitivity, specificity, accuracy, positive predictive value, andnegative predictive value of SWE and TE, as well as the kappa index through cross-analysisof SWE, TE, and liver biopsy. [Results] For liver hardness, the sensitivity of SWE was84.39%, the specificity of SWE was 97.92%, the accuracy of SWE was 87.33%, the positivepredictive value of SWE was 99.32%, and the negative predictive value of SWE was 63.51%.The sensitivity of TE was 94.80%, the specificity of TE was 77.08%, the accuracy of TE was90.95%, the positive predictive value of TE was 93.97%, and the negative predictive valueof TE was 80.43%. [Conclusion] It is our opinion that SWE and TE are non-invasive methodsthat are more effective than the invasive methods used for diagnosing liver hardness.Invasive methods cover only a section of liver tissue, and are more likely to cause sideeffects during biopsy.
ISSN	09155287
Volume Number	27
PubMed Central reference number	PMC4563291
Issue Number	8
PubMed reference number	26357427
Journal	Journal of Physical Therapy Science [J Phys Ther Sci]
e-ISSN	21875626
DOI	10.1589/jpts.27.2465
Language	English
Publisher	The Society of Physical Therapy Science
Publisher Date	2015-08-21
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the CreativeCommons Attribution Non-Commercial No Derivatives (by-nc-nd) License. 2015©by the Society of Physical Therapy Science. Published by IPECInc.
Subject Keyword	TE SWE Sensitivity
Content Type	Text
Resource Type	Article
Subject	Physical Therapy, Sports Therapy and Rehabilitation