Hypermetabolism of Olivary Nuclei in a Patient with Progressive Ataxia and Palatal Tremor.

Content Provider	Europe PMC
Author	Korpela, Jaana Joutsa, Juho Rinne, Juha O. Bergman, Jörgen Kaasinen, Valtteri
Editor	Louis, Elan D.
Copyright Year	2015
Abstract	BackgroundThe pathophysiology of the movement disorder progressive ataxia with palatal tremor (PAPT) is unclear.Case reportA 77-year-old male presented with dysarthria, ataxia, and 1–2 Hz palatal tremor. A diagnosis of probable sporadic PAPT was established. Brain magnetic resonance imaging was normal at the presymptomatic phase but later showed olivary hypertrophy. Brain [18F]-fludeoxyglucose (FDG) positron emission tomography (PET) showed bilateral hypermetabolism in the olivary nuclei.DiscussionThis second reported patient with PAPT and FDG-PET shows that olivary hypertrophy is paralleled with hypermetabolism. The olivary nuclei pathology also appears to be temporally associated with symptom onset.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4557084&blobtype=pdf
Page Count	2
Journal	Tremor and Other Hyperkinetic Movements [Tremor Other Hyperkinet Mov (N Y)]
Volume Number	5
PubMed Central reference number	PMC4557084
PubMed reference number	26339529
e-ISSN	21608288
DOI	10.7916/d8pv6jmt
Language	English
Publisher	Columbia University Libraries/Information Services
Publisher Date	2015-08-31
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
Subject Keyword	Palatal tremor ataxia olivary nuclei positron emission tomography
Content Type	Text
Resource Type	Article
Subject	Medicine