NDLI: Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A Review.

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Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A Review.

Content Provider	Europe PMC
Author	Gavriilidis, Paschalis Giakoustidis, Alexandros Giakoustidis, Dimitrios
Copyright Year	2015
Abstract	Aurora kinases (AKs) represent a novel group of serine/threonine kinases. They were originally described in 1995 by David Glover in the course of studies of mutant alleles characterized with unusual spindle pole configuration in Drosophila melanogaster. Thus far, three AKs A, B, and C have been discovered in human healthy and neoplastic cells. Each one locates in different subcellular locations and they are all nuclear proteins. AKs are playing an essential role in mitotic events such as monitoring of the mitotic checkpoint, creation of bipolar mitotic spindle and alignment of centrosomes on it, also regulating centrosome separation, bio-orientation of chromosomes and cytokinesis. Any inactivation of them can have catastrophic consequences on mitotic events of spindle formation, alignment of centrosomes and cytokinesis, resulting in apoptosis. Overexpression of AKs has been detected in diverse solid and hematological cancers and has been linked with a dismal prognosis. After discovery and identification of the first aurora kinase inhibitor (AKI) ZM447439 as a potential drug for targeted therapy in cancer treatment, approximately 30 AKIs have been introduced in cancer treatment.
ISSN	19183003
Journal	Journal of Clinical Medicine Research
Volume Number	7
PubMed Central reference number	PMC4554212
Issue Number	10
PubMed reference number	26345296
e-ISSN	19183011
DOI	10.14740/jocmr2295w
Language	English
Publisher	Elmer Press
Publisher Date	2015-08-23
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright 2015, Gavriilidis et al.
Subject Keyword	Serine/threonine kinases Aurora kinases A, B and C Aurora kinase inhibitors
Content Type	Text
Resource Type	Article
Subject	Medicine

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