NDLI: Blocking of rat hippocampal Cx36 by quinine accelerates kindling epileptogenesis.

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Blocking of rat hippocampal Cx36 by quinine accelerates kindling epileptogenesis.

Content Provider	Europe PMC
Author	Ghanbarabadi, Jafar Kazemi Sayyah, Mohammad
Copyright Year	2013
Abstract	There are abundant studies indicating that blocking gap junctions (GJs) containing connexin 36 (Cx36) inhibit seizures. However, recent evidences demonstrate proconvulsant effect of such intervention. Electrical coupling between GABAergic interneurons in CA1 region of hippocampus is mediated through Cx36 GJs. We investigated effect of quinine, a specific blocker of Cx36, on the seizure severity and epileptogenesis in amygala kindling model of epilepsy in rats. Quinine (1, 50, 100, 500 and 2000 µM/rat) was injected directly into the CA1 and kindled seizure parameters including behavioral seizure stage, duration of evoked afterdischarges, and duration of generalized seizures behavior were recorded 10 min afterward. Moreover, quinine (1, 30, and 100 µM/rat) was injected intra CA1 once daily during kindling development. At the doses used, quinine had no significant effect on amygdala-kindled seizures. However, quinine 100 µM significantly accelerated kindling rate. Blockade of Cx36 GJs coupling and consequent disruption of inhibitory transmission in GABAergic interneurons in CA1 area seems to be responsible for the antiepileptogenic effect of quinine.
Journal	EXCLI Journal
Volume Number	12
PubMed Central reference number	PMC4552103
PubMed reference number	26417230
e-ISSN	16112156
Language	English
Publisher	Leibniz Research Centre for Working Environment and Human Factors
Publisher Date	2013-03-14
Access Restriction	Open
Rights License	This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited. Copyright © 2013 Ghanbarabadi et al.
Subject Keyword	Cx36 CA1 amygdala kindling quinine
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Animal Science and Zoology Molecular Medicine

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