NDLI: Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors.

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Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors.

Content Provider	Europe PMC
Author	Zhao, Hai-yang Wu, Jiang Zhu, Jing-jing Xiao, Ze-cong He, Chao-chao Shi, Hong-xue Li, Xiao-kun Yang, Shu-lin Xiao, Jian
Copyright Year	2015
Abstract	Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instable in vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factors in vivo has become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing should enhance the growth factor's application in tissue regeneration. Thus, this study reviews current research on commonly used carriers for sustained release of growth factors and their sustained release effects for preservation of their bioactivity and their accomplishment in tissue engineering approaches.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2015
PubMed Central reference number	PMC4548067
PubMed reference number	26347885
e-ISSN	23146141
DOI	10.1155/2015/808202
Language	English
Publisher	Hindawi
Publisher Date	2015-08-11
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Hai-yang Zhao et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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