Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis.

Content Provider	Europe PMC
Author	Ohtori, Seiji Orita, Sumihisa Yamauchi, Kazuyo Eguchi, Yawara Ochiai, Nobuyasu Kishida, Shunji Kuniyoshi, Kazuki Aoki, Yasuchika Nakamura, Junichi Ishikawa, Tetsuhiro Miyagi, Masayuki Kamoda, Hiroto Suzuki, Miyako Kubota, Gou Sakuma, Yoshihiro Oikawa, Yasuhiro Inage, Kazuhide Sainoh, Takeshi Sato, Jun Shiga, Yasuhiro Abe, Koki Fujimoto, Kazuki Kanamoto, Hiroto Toyone, Tomoaki Inoue, Gen Takahashi, Kazuhisa
Copyright Year	2015
Abstract	PurposeOsteoarthritic (OA) pain is largely considered to be inflammatory pain. However, during the last stage of knee OA, sensory nerve fibers in the knee are shown to be significantly damaged when the subchondral bone junction is destroyed, and this can induce neuropathic pain. Several authors have reported that tumor necrosis factor-α (TNFα) in a knee joint plays a crucial role in pain modulation. The purpose of the current study was to evaluate the efficacy of etanercept, a TNFα inhibitor, for pain in knee OA.Materials and MethodsThirty-nine patients with knee OA and a 2-4 Kellgren-Lawrence grading were evaluated in this prospective study. Patients were divided into two groups; hyaluronic acid (HA) and etanercept injection. All patients received a single injection into the knee. Pain scores were evaluated before and 4 weeks after injection using a visual analogue scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and they were compared between the groups.ResultsBefore injection, VAS and WOMAC scores were not significantly different between the groups (p>0.05). Significant pain relief was found in the etanercept group at 1 and 2 weeks by VAS, and at 4 weeks by WOMAC score, compared with the HA group (p<0.05). No adverse events were observed in either group.ConclusionDirect injection of etanercept into OA knee joints was an effective treatment for pain in moderate and severe OA patients. Furthermore, this finding suggests that TNFα is one factor that induces OA pain.
ISSN	05135796
Volume Number	56
PubMed Central reference number	PMC4541670
Issue Number	5
PubMed reference number	26256983
Journal	Yonsei Medical Journal [Yonsei Med. J]
e-ISSN	19762437
DOI	10.3349/ymj.2015.56.5.1379
Language	English
Publisher	Yonsei University College of Medicine
Publisher Date	2015-09-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2015
Subject Keyword	Etanercept knee osteoarthritis pain
Content Type	Text
Resource Type	Article
Subject	Medicine