NDLI: miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies.

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miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies.

Content Provider	Europe PMC
Author	Amodio, Nicola Rossi, Marco Raimondi, Lavinia Pitari, Maria Rita Botta, Cirino Tagliaferri, Pierosandro Tassone, Pierfrancesco
Copyright Year	2015
Abstract	A wealth of studies has highlighted the biological complexity of hematologic malignancies and the role of dysregulated signal transduction pathways. Along with the crucial role of genetic abnormalities, epigenetic aberrations are nowadays emerging as relevant players in cancer development, and significant research efforts are currently focusing on mechanisms by which histone post-translational modifications, DNA methylation and noncoding RNAs contribute to the pathobiology of cancer. As a consequence, these studies have provided the rationale for the development of epigenetic drugs, such as histone deacetylase inhibitors and demethylating compounds, some of which are currently in advanced phase of pre-clinical investigation or in clinical trials. In addition, a more recent body of evidence indicates that microRNAs (miRNAs) might target effectors of the epigenetic machinery, which are aberrantly expressed or active in cancers, thus reverting those epigenetic abnormalities driving tumor initiation and progression. This review will focus on the broad epigenetic activity triggered by members of the miR-29 family, which underlines the potential of miR-29s as candidate epi-therapeutics for the treatment of hematologic malignancies.
Journal	Oncotarget
Volume Number	6
PubMed Central reference number	PMC4536984
Issue Number	15
PubMed reference number	25968566
e-ISSN	19492553
DOI	10.18632/oncotarget.3805
Language	English
Publisher	Impact Journals LLC
Publisher Date	2015-05-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2015 Amodio et al.
Subject Keyword	miR-29a miR-29b miR-29c hematologic malignancies multiple myeloma
Content Type	Text
Resource Type	Article
Subject	Oncology

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