NDLI: Interaction of AIM with insulin-like growth factor-binding protein-4.

Please wait, while we are loading the content...

Interaction of AIM with insulin-like growth factor-binding protein-4.

Content Provider	Europe PMC
Author	YOU, QIANG WU, YAN YAO, NANNAN SHEN, GUANNAN ZHANG, YING XU, LIANGGUO LI, GUIYING JU, CYNTHIA
Copyright Year	2015
Abstract	Apoptosis inhibitor of macrophages (AIM/cluster of differentiation 5 antigen-like/soluble protein α) has been shown to inhibit cellular apoptosis; however, the underlying molecular mechanism has not been elucidated. Using yeast two-hybrid screening, the present study uncovered that AIM binds to insulin-like growth factor binding protein-4 (IGFBP-4). AIM interaction with IGFBP-4, as well as IGFBP-2 and -3, but not with IGFBP-1, -5 and -6, was further confirmed by co-immunoprecipitation (co-IP) using 293 cells. The binding activity and affinity between AIM and IGFBP-4 in vitro were analyzed by co-IP and biolayer interferometry. Serum depletion-induced cellular apoptosis was attenuated by insulin-like growth factor-I (IGF-I), and this effect was abrogated by IGFBP-4. Of note, in the presence of AIM, the inhibitory effect of IGFBP-4 on the anti-apoptosis function of IGF-I was attenuated, possibly through binding of AIM with IGFBP-4. In conclusion, to the best of our knowledge, the present study provides the first evidence that AIM binds to IGFBP-2, -3 and -4. The data suggest that this interaction may contribute to the mechanism of AIM-mediated anti-apoptosis function.
ISSN	11073756
Journal	International Journal of Molecular Medicine
Volume Number	36
PubMed Central reference number	PMC4533773
Issue Number	3
PubMed reference number	26135353
e-ISSN	1791244X
DOI	10.3892/ijmm.2015.2262
Language	English
Publisher	D.A. Spandidos
Publisher Date	2015-06-26
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2015, Spandidos Publications
Subject Keyword	apoptosis inhibitor of macrophage insulin-like growth factor-binding protein-4 insulin-like growth factor protein interaction apoptosis
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interaction of AIM with insulin-like growth factor-binding protein-4

Interaction of AIM with insulin-like growth factor-binding protein-4

Studies on regulation of insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-4 production in human bone cells.

Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells

Disulfide linkages of insulin-like growth factor binding protein-4.

Age related secretary pattern of growth hormone, insulin-like growth factor-I & insulin-like growth factor binding protein-3 in postmenopausal women

Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.

Effect of growth hormone administration to mature miniature Brahman cattle treated with or without insulin on circulating concentrations of insulin-like growth factor-I and other metabolic hormones and metabolites.

Growth Hormone Insulin-Like Growth Factor 1 Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 3 (2011)

Interaction of AIM with insulin-like growth factor-binding protein-4.

Similar Documents

Interaction of AIM with insulin-like growth factor-binding protein-4

Interaction of AIM with insulin-like growth factor-binding protein-4

Studies on regulation of insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-4 production in human bone cells.

Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells

Disulfide linkages of insulin-like growth factor binding protein-4.

Age related secretary pattern of growth hormone, insulin-like growth factor-I & insulin-like growth factor binding protein-3 in postmenopausal women

Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.

Effect of growth hormone administration to mature miniature Brahman cattle treated with or without insulin on circulating concentrations of insulin-like growth factor-I and other metabolic hormones and metabolites.

Growth Hormone Insulin-Like Growth Factor 1 Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 3 (2011)

Interaction of AIM with insulin-like growth factor-binding protein-4.