NDLI: Sweet's syndrome during the treatment of acute promyelocytic leukemia with all-trans retinoic acid.

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Sweet's syndrome during the treatment of acute promyelocytic leukemia with all-trans retinoic acid.

Content Provider	Europe PMC
Author	Park, Chi Jun Bae, Young Deok Choi, Ji Yong Heo, Pil Seog Lee, Keun Seok Park, Young Suk Lee, Jung-Ae
Copyright Year	2001
Abstract	All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Quite many ATRA-related side effects, including retinoic acid syndrome, were reported. So far, it has rarely been reported that Sweet’s syndrome, characterized by fever, neutrophilia, painful erythematous cutaneous plaques, dense dermal infiltrates of mature neutrophils and rapid response to steroid therapy, is associated with ATRA. In the case that Sweet’s syndrome associated with ATRA is found, physicians will have to face a great challenge over the possibility of infectious conditions. We present here a case of Sweet’s syndrome associated with ATRA. A 35-year-old female with APL developed fever, painful erythematous cutaneous plaques on both cheeks, right wrist and both shins during induction chemotherapy with ATRA. A skin biopsy revealed a dense dermal infiltrate, consisting of mature neutrophils without vasculitis or cutaneous immunoglobulin deposits, which is compatible with Sweet’s syndrome. Oral prednisone was administered and the lesions started to improve within 48 hours.
ISSN	12263303
Volume Number	16
PubMed Central reference number	PMC4531725
Issue Number	3
PubMed reference number	11769583
Journal	The Korean Journal of Internal Medicine [Korean J. Intern. Med]
e-ISSN	20056648
DOI	10.3904/kjim.2001.16.3.218
Language	English
Publisher	Korean Association of Internal Medicine
Publisher Date	2001-09-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2001 The Korean Association of Internal Medicine
Subject Keyword	Sweet’s syndrome all-trans retinoic acid acute promyelocytic leukemia
Content Type	Text
Resource Type	Article
Subject	Internal Medicine

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