NDLI: Transdermal Nicotine Application Attenuates Cardiac Dysfunction after Severe Thermal Injury.

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Transdermal Nicotine Application Attenuates Cardiac Dysfunction after Severe Thermal Injury.

Content Provider	Europe PMC
Author	Claassen, Leif Papst, Stephan Reimers, Kerstin Stukenborg-Colsman, Christina Steinstraesser, Lars Vogt, Peter M. Kraft, Theresia Niederbichler, Andreas D.
Copyright Year	2015
Abstract	Background. Severe burn trauma leads to an immediate and strong inflammatory response inciting cardiac dysfunction that is associated with high morbidity and mortality. The aim of this study was to determine whether transdermal application of nicotine could influence the burn-induced cardiac dysfunction via its known immunomodulatory effects. Material and Methods. A standardized rat burn model was used in 35 male Sprague Dawley rats. The experimental animals were divided into a control group, a burn trauma group, a burn trauma group with additional nicotine treatment, and a sham group with five experimental animals per group. The latter two groups received nicotine administration. Using microtip catheterization, functional parameters of the heart were assessed 12 or 24 hours after infliction of burn trauma. Results. Burn trauma led to significantly decreased blood pressure (BP) values whereas nicotine administration normalized BP. As expected, burn trauma also induced a significant deterioration of myocardial contractility and relaxation parameters. After application of nicotine these adverse effects were attenuated. Conclusion. The present study showed that transdermal nicotine administration has normalizing effects on burn-induced myocardial dysfunction parameters. Further research is warranted to gain insight in molecular mechanisms and pathways and to evaluate potential treatment options in humans.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2015
PubMed Central reference number	PMC4531159
PubMed reference number	26290866
e-ISSN	23146141
DOI	10.1155/2015/292076
Language	English
Publisher	Hindawi
Publisher Date	2015-07-28
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Leif Claassen et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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