NDLI: Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes.

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Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes.

Content Provider	Europe PMC
Author	Subongkot, Thirapit Ngawhirunpat, Tanasait
Copyright Year	2015
Abstract	The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin labels for phospholipid bilayer fluidity at the C5 atom of the acyl chain near the polar head group (hydrophilic region) and the C16 atom of the acyl chain (lipophilic region), respectively. The electron spin resonance study revealed that Tween 20 increased the fluidity at the C5 atom of the acyl chain, whereas terpenes increased the fluidity at the C16 atom of the acyl chain of the phospholipid bilayer. The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein. Confocal laser scanning microscopy showed that ultradeformable liposomes with terpenes increase the skin penetration of sodium fluorescein by enhancing hair follicle penetration.
ISSN	11769114
Journal	International Journal of Nanomedicine
Volume Number	10
PubMed Central reference number	PMC4514352
PubMed reference number	26229462
e-ISSN	11782013
DOI	10.2147/ijn.s86624
Language	English
Publisher	Dove Medical Press
Publisher Date	2015-07-10
Access Restriction	Open
Rights License	The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. © 2015 Subongkot and Ngawhirunpat. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License
Subject Keyword	ultradeformable liposomes terpenes fluidity electron spin resonance spectroscopy confocal laser scanning microscopy
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science

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