NDLI: Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: a meta-analysis.

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Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: a meta-analysis.

Content Provider	Europe PMC
Author	Zhang, Ying Zheng, Yu-xin Zhu, Jun-ming Zhang, Jian-min Zheng, Zhe
Copyright Year	2015
Abstract	Objective: The aim of our meta-analysis was to assess the effects of antiepileptic drugs on bone mineral density and bone metabolism in epileptic children. Methods: Searches of PubMed and Web of Science were undertaken to identify studies evaluating the association between antiepileptic drugs and bone mineral density and bone metabolism. Results: A total of 22 studies with 1492 subjects were included in our research. We identified: (1) a reduction in bone mineral density at lumbar spine (standardized mean difference (SMD)=−0.30, 95% confidence interval (CI) [−0.61, −0.05]), trochanter (mean difference (MD)=−0.07, 95% CI [−0.10, −0.05]), femoral neck (MD=−0.05, 95% CI [−0.09, −0.02]), and total body bone mineral density (MD=−0.33, 95% CI [−0.51, −0.15]); (2) a reduction in 25-hydroxyvitamin D (MD=−3.37, 95% CI [−5.94, −0.80]) and an increase in serum alkaline phosphatase (SMD=0.71, 95% CI [0.38, 1.05]); (3) no significant changes in serum parathyroid hormone, calcium, or phosphorus. Conclusions: Our meta-analysis suggests that treatment with antiepileptic drugs may be associated with decreased bone mineral density in epileptic children.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4506952&blobtype=pdf
ISSN	16731581
Volume Number	16
PubMed Central reference number	PMC4506952
Issue Number	7
PubMed reference number	26160719
Journal	Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B]
e-ISSN	18621783
DOI	10.1631/jzus.b1500021
Language	English
Publisher	Zhejiang University Press
Publisher Date	2015-07-01
Publisher Place	Hangzhou
Access Restriction	Open
Rights License	Copyright © Zhejiang University and Springer-Verlag Berlin Heidelberg 2015
Subject Keyword	Antiepileptic drugs Bone mineral density Bone metabolism Children Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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