NDLI: Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.

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Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.

Content Provider	Europe PMC
Author	Ko, Hyeonseok Jeong, Mi-Hyeon Jeon, Hyelin Sung, Gi-Jun So, Youngsin Kim, InKi Son, JaeKyoung Lee, Sang-wook Yoon, Ho-Geun Choi, Kyung-Chul
Copyright Year	2015
Abstract	TRAIL can induce apoptosis in some cancer cells and is an immune effector in the surveillance and elimination of developing tumors. Yes, some cancers are resistant to TRAIL. Delphinidin, a polyphenolic compound contained in brightly colored fruits and vegetables, has anti-inflammatory, anti-oxidant, and anti-tumorigenic activities. Here we showed that delphinidin sensitized TRAIL-resistant human prostate cancer cells to undergo apoptosis. Cells treated with delphinidin and TRAIL activated the extrinsic and intrinsic pathways of caspase activation. TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3). In conclusion, delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis by inducing DR5, thus causing caspase-mediated HDAC3 cleavage. Our data reveal a potential way of chemoprevention of prostate cancer by enabling TRAIL-mediated apoptosis.
Journal	Oncotarget
Volume Number	6
PubMed Central reference number	PMC4496411
Issue Number	12
PubMed reference number	25991668
e-ISSN	19492553
DOI	10.18632/oncotarget.3667
Language	English
Publisher	Impact Journals LLC
Publisher Date	2015-04-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2015 Ko et al.
Subject Keyword	delphinidin TRAIL apoptosis HDAC3 prostate cancer
Content Type	Text
Resource Type	Article
Subject	Oncology

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