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APOE Polymorphism Is Associated with C-reactive Protein Levels but Not with White Blood Cell Count: Dong-gu Study and Namwon Study.
| Content Provider | Europe PMC |
|---|---|
| Author | Yun, Yong-Woon Kweon, Sun-Seog Choi, Jin-Su Rhee, Jung-Ae Lee, Young-Hoon Nam, Hae-Sung Jeong, Seul-Ki Park, Kyeong-Soo Ryu, So-Yeon Choi, Seong-Woo Kim, Hee Nam Cauley, Jane A. Shin, Min-Ho |
| Copyright Year | 2015 |
| Abstract | We evaluated the association of the APOE polymorphism with serum C-reactive protein levels and white blood cell count in two large population-based studies in Korean. The datasets included the Dong-gu study (n = 8,893) and the Namwon Study (n = 10,032). APOE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. Multivariable linear regression analysis was performed to evaluate the relationship of APOE genotypes with C-reactive protein levels and white blood cell count with adjustments for age, sex, body mass index, smoking, diabetes, hypertension, and serum lipids. In the multivariate model, carriers of E3E4 or E4E4 genotype had significantly lower C-reactive protein levels compared with carriers of E3E3 genotype group (0.50 mg/L vs. 0.67 mg/L; 0.37 mg/L vs. 0.67 mg/L, respectively, for the Dong-gu Study and 0.47 mg/L vs. 0.66 mg/L; 0.45 mg/L vs. 0.66 mg/L, respectively, for the Namwon Study). However, there was no difference in white blood cell count among APOE genotypes. We found that the APOE E4 allele is associated with lower C-reactive protein levels, but not white blood cell count. Our results suggest that APOE genotype may influence C-reactive protein levels through non-inflammatory pathway.Graphical Abstract |
| ISSN | 10118934 |
| Volume Number | 30 |
| PubMed Central reference number | PMC4479937 |
| Issue Number | 7 |
| PubMed reference number | 26130946 |
| Journal | Journal of Korean Medical Science [J. Korean Med. Sci] |
| e-ISSN | 15986357 |
| DOI | 10.3346/jkms.2015.30.7.860 |
| Language | English |
| Publisher | The Korean Academy of Medical Sciences |
| Publisher Date | 2015-06-10 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2015 The Korean Academy of Medical Sciences. |
| Subject Keyword | C-reactive Protein Apolipoprotein E Polymorphism, Genetic Inflammation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
