NDLI: Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis.

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Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis.

Content Provider	Europe PMC
Author	Falomo, Maria Elena Ferroni, Letizia Tocco, Ilaria Gardin, Chiara Zavan, Barbara
Copyright Year	2015
Abstract	Endometriosis is a degenerative process due to a chronic inflammatory damage leading to extracellular matrix components deposition and glandular fibrosis. It is known that mesenchymal stem cells secrete a wide range of bioactive molecules, some of them modulating the immune inflammatory response, and others providing regeneration and remodeling of injured tissue. We have performed in vitro experiments in order to analyze the capability of allogenic equine adipose-derived stem cells (ADSCs) to infiltrate mares' endometrial tissues and to stimulate the expression of cytokines and metallopeptidases. Differences in the biologic response to the exposure to ADSCs between pathological and healthy endometrial tissue have been identified. These results could challenge researchers to progress forward with future studies for the development of a biological therapy with a possible application in translational medicine.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2015
PubMed Central reference number	PMC4477049
PubMed reference number	26180781
e-ISSN	23146141
DOI	10.1155/2015/141485
Language	English
Publisher	Hindawi
Publisher Date	2015-06-09
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Maria Elena Falomo et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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