Monoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart Surgery.

Content Provider	Europe PMC
Author	Duicu, Oana M. Lighezan, Rodica Sturza, Adrian Ceausu, Raluca A. Borza, Claudia Vaduva, Adrian Noveanu, Lavinia Gaspar, Marian Ionac, Adina Feier, Horea Muntean, Danina M. Mornos, Cristian
Copyright Year	2015
Abstract	Oxidative stress is a pathomechanism causally linked to the progression of chronic cardiovascular diseases and diabetes. Mitochondria have emerged as the most relevant source of reactive oxygen species, the major culprit being classically considered the respiratory chain at the inner mitochondrial membrane. In the past decade, several experimental studies unequivocally demonstrated the contribution of monoamine oxidases (MAOs) at the outer mitochondrial membrane to the maladaptative ventricular hypertrophy and endothelial dysfunction. This paper addresses the contribution of mitochondrial dysfunction to the pathogenesis of heart failure and diabetes together with the mounting evidence for an emerging role of MAO inhibition as putative cardioprotective strategy in both conditions.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2015
PubMed Central reference number	PMC4458524
PubMed reference number	26101773
e-ISSN	23146141
DOI	10.1155/2015/515437
Language	English
Publisher	Hindawi
Publisher Date	2015-05-25
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Oana M. Duicu et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology