NDLI: Frequency and specificity of red blood cell alloimmunization in chilean transfused patients.

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Frequency and specificity of red blood cell alloimmunization in chilean transfused patients.

Content Provider	Europe PMC
Author	Caamaño, José Musante, Evangelina Contreras, Margarita Ulloa, Hernán Reyes, Carolina Inaipil, Verónica Saavedra, Nicolás Guzmán, Neftalí
Copyright Year	2015
Abstract	Summary Background Alloimmunization is an adverse effect of blood transfusions. In Chile, alloimmunization frequency is not established, and for this reason the aim of this study was to investigate the prevalence and specificity of red blood cell (RBC) alloantibodies in Chilean transfused subjects. Methods Records from 4,716 multi-transfused patients were analyzed. In these patients, antibody screening was carried out prior to cross-matching with a commercially available two-cell panel by the microcolum gel test, and samples with a positive screen were analyzed for the specificity of the alloantibody with a 16-cell identification panel. Results The incidence of RBC alloimmunization in transfused patients was 1.02% (48/4,716) with a higher prevalence in women (40/48). We detected 52 antibodies, the most frequent specificities identified were anti-E (30.8%), anti-K (26.9%), anti-D (7.7%), and anti-Fya (5.8%). The highest incidence of alloantibodies was observed in cancer and gastroenterology patients. Conclusion The data demonstrated a low alloimmunization frequency in Chilean transfused patients, principally associated with antibodies anti-E, anti-K, anti-D, and anti-Fya.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4404896&blobtype=pdf
Page Count	4
ISSN	16603796
Volume Number	42
DOI	10.1159/000370136
PubMed Central reference number	PMC4404896
Issue Number	1
PubMed reference number	25960709
Journal	Transfusion Medicine and Hemotherapy [Transfus Med Hemother]
e-ISSN	16603818
Language	English
Publisher	Karger Publishers
Publisher Date	2014-12-19
Publisher Place	Germany
Access Restriction	Open
Rights License	Copyright © 2015 by S. Karger GmbH, Freiburg
Subject Keyword	Alloimmunization Unexpected antibodies Red blood cell transfusion
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Hematology

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