NDLI: Omentum Cells Promote Healing of Colonic Tissues in Dextran Sulfate Sodium (DSS) Induced Model of Colitis in Mice.

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Omentum Cells Promote Healing of Colonic Tissues in Dextran Sulfate Sodium (DSS) Induced Model of Colitis in Mice.

Content Provider	Europe PMC
Author	Jung, Byung Chul Lee, Min Ho Sethupathi, Periannan Lee, In-soo Lee, Dongsup Rhee, Ki-Jong
Copyright Year	2013
Abstract	BackgroundInflammatory bowel disease is characterized by persistent inflammation of the intestinal tissues. Although the usage of biologics has greatly enhanced the management of this disorder, a permanent treatment does not exist. In this study, we investigated whether the cells with anti-inflammatory and healing properties from the omentum could be harnessed to treat colitis in dextran sulfate sodium (DSS)-induced mouse colitis model.Methods:C57BL/6 mice were administered 2% DSS for 10 days and then injected in the peritoneum with cells isolated from the murine omentum. Thereafter, body weight change, serum KC levels, and histological analysis of the colon were conducted. We also examined if omentum infused mice were resistant to a lethal challenge of 4% DSS.Results:2% DSS-mice injected with omentum cells exhibited a decrease in body weight loss, decreased inflammation in the colon and decreased levels of the inflammatory cytokine KC in the serum compared to mice given 2% DSS alone. In addition, mice administered a lethal dose of 4% DSS exhibited a 50% decrease in mortality when injected with omentum cells.Conclusion:Cells from the omentum exert anti-inflammatory and/or healing properties in the acute DSS-induced colitis model.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4390752&blobtype=pdf
ISSN	22348549
Journal	Journal of Lifestyle Medicine [J Lifestyle Med]
Volume Number	3
PubMed Central reference number	PMC4390752
Issue Number	1
PubMed reference number	26064837
e-ISSN	22881557
Language	English
Publisher	Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine
Publisher Date	2013-03-31
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2013 Journal of Lifestyle Medicine
Subject Keyword	Omentum Stem cells Dextran sulfate sodium Colitis Inflammatory bowel disease
Content Type	Text
Resource Type	Article
Subject	Medicine

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