The prognostic role of Ki-67/MIB-1 in cervical cancer: a systematic review with meta-analysis.

Content Provider	Europe PMC
Author	Pan, Denghua Wei, Kanglai Ling, Yanxin Su, Shitao Zhu, Meilin Chen, Gang
Copyright Year	2015
Abstract	BackgroundA significant relationship has been reported in which Ki-67/MIB-1 expression is correlated with survival in cervical cancer patients. However, the prognostic value of Ki-67/MIB-1 in cervical cancer is still not well understood.Material/MethodA meta-analysis was carried out to explore the prognostic value of Ki-67/MIB-1 on overall survival (OS) and/or disease-free survival (DFS) in cervical cancer. The databases of PubMed, ISI Web of Science, EMBASE, Cochrane Central Register of Controlled Trials, ScienceDirect, and Wiley Online Library were used to identify relevant literature.ResultsWe included 18 studies covering 1344 patients in the meta-analysis. The effect of Ki-67/MIB-1 on OS for pooled random effects HR estimate was 1.63 (95% confidence intervals (CI) 1.09–2.45; P<0.05). Subgroup analysis by ethnicity suggested that high expression of Ki-67/MIB-1 had association with Asians (1.84, 95% CI 1.04–3.23), but not with Africans (HR=1.53, 95% CI 0.34–6.86) or Europeans (HR=1.29, 95% CI 0.74–2.23). Furthermore, subgroup analysis of diverse treatments revealed no difference in surgery (HR=1.97, 95% CI 0.78–4.99) and radiation therapy (RT) (HR=1.56, 95% CI 0.93–2.63). The pooled HR for DFS was 1.26 (95% CI 0.58–2.73; P>0.05) and the subgroup analysis indicated Ki-67/MIB1 was associated with DFS (HR=3.67, 95% CI 2.65–5.09) in Asians. In the treatment subgroup analysis, no direct value was found among surgery (HR=1.13, 95% CI 0.10–13.53) and RT (HR=1.26, 95% CI 0.71–2.24).ConclusionsOur meta-analysis concludes that Ki-67/MIB-1 had a prognostic value for OS in cervical cancer patients. To further evaluate the prognostic role of Ki-67/MIB-1 on DFS, studies with larger numbers of patients are needed to validate our findings.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	21
PubMed Central reference number	PMC4386420
PubMed reference number	25807305
e-ISSN	16433750
DOI	10.12659/msm.892807
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2015-03-25
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License © Med Sci Monit, 2015
Subject Keyword	Ki-67 Antigen Meta-Analysis Prognosis Uterine Cervical Neoplasms
Content Type	Text
Resource Type	Article
Subject	Medicine