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Lipid mediators are critical in resolving inflammation: a review of the emerging roles of eicosanoids in diabetes mellitus.
| Content Provider | Europe PMC |
|---|---|
| Author | Tessaro, Fernando H. G. Ayala, Thais S. Martins, Joilson O. |
| Copyright Year | 2015 |
| Abstract | The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM). A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the progression of diabetes complications. Our review presents recent knowledge about eicosanoid synthesis and signaling in DM-related complications, and discusses eicosanoid-related target therapeutics. |
| ISSN | 23146133 |
| Journal | Biomed Research International |
| Volume Number | 2015 |
| PubMed Central reference number | PMC4383369 |
| PubMed reference number | 25866794 |
| e-ISSN | 23146141 |
| DOI | 10.1155/2015/568408 |
| Language | English |
| Publisher | Hindawi |
| Publisher Date | 2015-03-19 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Fernando H. G. Tessaro et al. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |