Metastatic Neuroendocrine Tumour in a Renal Transplant Recipient: Dual-Tracer PET-CT with (18)F-FDG and (68)Ga-DOTANOC in This Rare Setting.

Content Provider	Europe PMC
Author	Karunanithi, Sellam Roy, Shambo Guha Sharma, Punit Yadav, Rajni Bal, Chandrasekhar Kumar, Rakesh
Abstract	Recipients of renal transplant are at increased risk of developing various malignancies, especially post-transplant lymphoproliferative disorder (PTLD) and skin cancers. Neuroendocrine tumours (NET) of the gastrointestinal tract have not been reported in this setting. Here we describe the case of a 75-year-old male who had undergone renal transplant 8 years back and now presented with significant weight loss and backache, clinically suspected as PTLD. 18F-Fluordeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) showed hypermetabolic lesions in the liver and rectum, raising the suspicion of PTLD. However, biopsy from the liver lesion showed poorly differentiated NET. 68Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-octreotide (68Ga-DOTANOC) PET-CT was then done, which confirmed the primary lesion in the rectum with liver metastases.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4354792&blobtype=pdf
ISSN	18693474
Volume Number	49
DOI	10.1007/s13139-014-0297-x
PubMed Central reference number	PMC4354792
Issue Number	1
PubMed reference number	25767623
Journal	Nuclear Medicine and Molecular Imaging [Nucl Med Mol Imaging]
e-ISSN	18693482
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-10-17
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	© Korean Society of Nuclear Medicine 2014
Subject Keyword	Neuroendocrine tumour PET-CT 68Ga-DOTANOC 18F-FDG Post-transplant lymphoproliferative disorder
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging