NDLI: Cardiac function in a long-term follow-up study of moderate and severe porcine model of chronic myocardial infarction.

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Cardiac function in a long-term follow-up study of moderate and severe porcine model of chronic myocardial infarction.

Content Provider	Europe PMC
Author	de Jong, Renate van Hout, Gerardus P. J. Houtgraaf, Jaco H. Takashima, S. Pasterkamp, Gerard Hoefer, Imo Duckers, Henricus J.
Copyright Year	2015
Abstract	Background. Novel therapies need to be evaluated in a relevant large animal model that mimics the clinical course and treatment in a reasonable time frame. To reliably assess therapeutic efficacy, knowledge regarding the translational model and the course of disease is needed. Methods. Landrace pigs were subjected to a transient occlusion of the proximal left circumflex artery (LCx) (n = 6) or mid-left anterior descending artery (LAD) (n = 6) for 150 min. Cardiac function was evaluated before by 2D echocardiography or 3D echocardiography and pressure-volume loop analysis. At 12 weeks of follow-up the heart was excised for histological analysis and infarct size calculations. Results. Directly following AMI, LVEF was severely reduced compared to baseline in the LAD group (−17.1 ± 1.6%, P = 0.009) compared to only a moderate reduction in the LCx group (−5.9 ± 1.5%, P = 0.02) and this effect remained unchanged during 12 weeks of follow-up. Conclusion. Two models of chronic MI, representative for different patient groups, can reproducibly be created through clinically relevant ischemia-reperfusion of the mid-LAD and proximal LCx.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2015
PubMed Central reference number	PMC4352740
PubMed reference number	25802838
e-ISSN	23146141
DOI	10.1155/2015/209315
Language	English
Publisher	Hindawi
Publisher Date	2015-02-23
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Renate de Jong et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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