NDLI: MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion.

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MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion.

Content Provider	Europe PMC
Author	Ak, Guntulu Tomaszek, Sandra C. Kosari, Farhad Metintas, Muzaffer Jett, James R. Metintas, Selma Yildirim, Huseyin Dundar, Emine Dong, Jie Aubry, Marie Christine Wigle, Dennis A. Thomas, Charles F.
Copyright Year	2015
Abstract	Introduction. We investigated the expression of microRNAs and mRNAs in pleural tissues from patients with either malignant pleural mesothelioma or benign asbestos-related pleural effusion. Methods. Fresh frozen tissues from a total of 18 malignant pleural mesothelioma and 6 benign asbestos-related pleural effusion patients were studied. Expression profiling of mRNA and microRNA was performed using standard protocols. Results. We discovered significant upregulation of multiple microRNAs in malignant pleural mesothelioma compared to benign asbestos-related pleural effusion. Hsa-miR-484, hsa-miR-320, hsa-let-7a, and hsa-miR-125a-5p were able to discriminate malignant from benign disease. Dynamically regulated mRNAs were also identified. MET was the most highly overexpressed gene in malignant pleural mesothelioma compared to benign asbestos-related pleural effusion. Integrated analyses examining microRNA-mRNA interactions suggested multiple altered targets within the Notch signaling pathway. Conclusions. Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2015
PubMed Central reference number	PMC4331157
PubMed reference number	25756049
e-ISSN	23146141
DOI	10.1155/2015/635748
Language	English
Publisher	Hindawi
Publisher Date	2015-02-01
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Guntulu Ak et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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