NDLI: Clinical and prognostic features of erionite-induced malignant mesothelioma.

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Clinical and prognostic features of erionite-induced malignant mesothelioma.

Content Provider	Europe PMC
Author	Demirer, Ersin Ghattas, Christian F. Radwan, Mohamed O. Elamin, Elamin M.
Copyright Year	2015
Abstract	This review analytically examines the published data for erionite-related malignant pleural mesothelioma (E-MPM) and any data to support a genetically predisposed mechanism to erionite fiber carcinogenesis. Adult patients of age ≥18 years with erionite-related pleural diseases and genetically predisposed mechanisms to erionite carcinogenesis were included, while exclusion criteria included asbestos- or tremolite-related pleural diseases. The search was limited to human studies though not limited to a specific timeframe. A total of 33 studies (31042 patients) including 22 retrospective studies, 6 prospective studies, and 5 case reports were reviewed. E-MPM developed in some subjects with high exposures to erionite, though not all. Chest CT was more reliable in detecting various pleural changes in E-MPM than chest X-ray, and pleural effusion was the most common finding in E-MPM cases, by both tests. Bronchoalveolar lavage remains a reliable and relatively less invasive technique. Chemotherapy with cisplatin and mitomycin can be administered either alone or following surgery. Erionite has been the culprit of numerous malignant mesothelioma cases in Europe and even in North America. Erionite has a higher degree of carcinogenicity with possible genetic transmission of erionite susceptibility in an autosomal dominant fashion. Therapeutic management for E-MPM remains very limited, and cure of the disease is extremely rare.
ISSN	05135796
Volume Number	56
PubMed Central reference number	PMC4329339
Issue Number	2
PubMed reference number	25683976
Journal	Yonsei Medical Journal [Yonsei Med. J]
e-ISSN	19762437
DOI	10.3349/ymj.2015.56.2.311
Language	English
Publisher	Yonsei University College of Medicine
Publisher Date	2015-03-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2015
Subject Keyword	Asbestos malignant mesothelioma pleural effusion
Content Type	Text
Resource Type	Article
Subject	Medicine

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