Can hyaluronan binding assay predict the outcome of intrauterine insemination in couples with unexplained or mild male factor infertility?

Content Provider	Europe PMC
Author	Yildirim, Melahat Duvan, Candan Iltemir Pekel, Aslihan Ayrim, Aylin Kafali, Hasan
Copyright Year	2015
Abstract	BackgroundThe purpose of this study was to evaluate the prognostic effect of Hyaluronan Binding Assay (HBA) which has been used as a method of sperm selection for intracytoplasmic sperm injection procedure, on the outcome of intrauterine insemination (IUI) in couples with unexplained or mild male factor infertility.Methods77 infertile couples were enrolled in our study. On the day of IUI procedure, HBA test was performed by using fresh semen samples, and the rates of sperm binding to HBA were calculated. HBA values and semen parameters were compared. Fisher exact test was used to evaluate the relationship between HBA ratio and pregnancy status. Mann-Whitney U test was used to compare quantitative variables between pregnant and non-pregnant groups. The p < 0.05 was considered statistically significant.ResultsIn this study, HBA ratio was 69(29.25%) and pregnancy rate was 14.29%. A significant positive correlation between HBA and total motile sperm count, inseminating sperm count, progressive motility, morphology, and sperm concentration (p < 0.001, p < 0.001, p:0.007, p < 0.003, p:0.003 respectively) was observed. Although HBA values in pregnant group were higher than those in non-pregnant group, this result did not reach the statistically significant level (HBA: 67(20%) for non-pregnant group, 80.5(21.3%) for pregnant group). Also, no relationship between HBA values and pregnancy status was found. Moreover, there was no significant correlation between pregnancy status and HBA ratios based on the suggested cut-off value of 60 in literature (p = 0.425).ConclusionHBA does not predict the IUI outcome in couples with unexplained infertility or mild male factor infertility, but it can be used together with semen parameters to verify sperm quality.
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ISSN	22285482
Journal	Journal of Reproduction & Infertility [J Reprod Infertil]
Volume Number	16
PubMed Central reference number	PMC4322176
Issue Number	1
PubMed reference number	25717431
e-ISSN	2251676X
Language	English
Publisher	Avicenna Research Institute
Publisher Date	2015-01-01
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. Copyright © 2015 Avicenna Research Institute
Subject Keyword	Hyaluronan binding assay Intrauterine insemination Mild male factor infertility Prediction Unexplained infertility
Content Type	Text
Resource Type	Article
Subject	Reproductive Medicine