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Improved C3-4 transfer for treatment of root avulsion of the brachial plexus upper trunk: Animal experiments and clinical application.
| Content Provider | Europe PMC |
|---|---|
| Author | Zou, Lin Cao, Xuecheng Li, Jing Liu, Lifeng Wang, Pingshan Cai, Jinfang |
| Copyright Year | 2012 |
| Abstract | Experimental rats with root avulsion of the brachial plexus upper trunk were treated with the improved C3-4 transfer for neurotization of C5-6. Results showed that Terzis grooming test scores were significantly increased at 6 months after treatment, the latency of C5-6 motor evoked potential was gradually shortened, and the amplitude was gradually increased. The rate of C3 instead of C5 and the C4 + phrenic nerve instead of C6 myelinated nerve fibers crossing through the anastomotic stoma was approximately 80%. Myelinated nerve fibers were arranged loosely but the thickness of the myelin sheath was similar to that of the healthy side. In clinical applications, 39 patients with root avulsion of the brachial plexus upper trunk were followed for 6 months to 4.5 years after treatment using the improved C3 instead of C5 nerve root transfer and C4 nerve root and phrenic nerve instead of C6 nerve root transfer. Results showed that the strength of the brachial biceps and deltoid muscles recovered to level III–IV, scapular muscle to level III–IV, latissimus dorsi and pectoralis major muscles to above level III, and the brachial triceps muscle to level 0–III. Results showed that the improved C3-4 transfer for root avulsion of the brachial plexus upper trunk in animal models is similar to clinical findings and that C3-4 and the phrenic nerve transfer for neurotization of C5-6 can innervate the avulsed brachial plexus upper trunk and promote the recovery of nerve function in the upper extremity. |
| ISSN | 16735374 |
| Volume Number | 7 |
| PubMed Central reference number | PMC4308750 |
| Issue Number | 20 |
| PubMed reference number | 25657692 |
| Journal | Neural Regeneration Research [Neural Regen Res] |
| e-ISSN | 18767958 |
| DOI | 10.3969/j.issn.1673-5374.2012.20.004 |
| Language | English |
| Publisher | Medknow Publications & Media Pvt Ltd |
| Publisher Date | 2012-07-01 |
| Publisher Place | India |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Neural Regeneration Research |
| Subject Keyword | brachial plexus cervical plexus upper trunk root avulsion nerve transfer phrenic nerve translational medicine peripheral nerve injury neural regeneration |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Neuroscience Neuroscience |
