The everolimus-eluting Xience stent in small vessel disease: bench, clinical, and pathology view.

Content Provider	Europe PMC
Author	Sanchez, Oscar D Yahagi, Kazuyuki Koppara, Tobias Virmani, Renu Joner, Michael
Copyright Year	2015
Abstract	Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. The pathogenesis of CAD relates to the presence of atherosclerotic plaques in the coronary arteries, which are most frequently treated today by percutaneous coronary intervention. Small vessel disease treatment represents one-third of all percutaneous coronary interventions with higher rates of restenosis and major adverse cardiac events. Initially, drug-eluting stents (DES) were developed to reduce in-stent restenosis, improving clinical outcomes and reducing the need for target vessel revascularization. However, late and very late stent thrombosis emerged as a new problem compromising DES’s long-term results. The cobalt–chromium everolimus-eluting stent (CoCr-EES) represents the results of an evolutionary process in DES technology aimed at improving the shortcomings of first-generation DES. Small vessel CAD has historically been an obstacle to long-term patency following implantation of DES. Antirestenotic efficacy has been shown to be of high relevance in small vessels. Therefore, stent selection may play an important role in determining outcomes in this subgroup of patients. This article will review the performance of CoCr-EES in the treatment of small vessel CAD from preclinical, clinical, and pathology perspectives, and it will highlight the most important findings in this regard.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4284006&blobtype=pdf
Journal	Medical Devices (Auckland, N.Z.) [Med Devices (Auckl)]
Volume Number	8
PubMed Central reference number	PMC4284006
PubMed reference number	25565907
e-ISSN	11791470
DOI	10.2147/mder.s50051
Language	English
Publisher	Dove Medical Press
Publisher Date	2014-12-30
Access Restriction	Open
Rights License	The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. © 2015 Sanchez et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License
Subject Keyword	small vessel cobalt–chromiun everolimus-eluting stent Xience V pathology
Content Type	Text
Resource Type	Article
Subject	Medicine Biomedical Engineering