NDLI: Anti-fatigue activities of polysaccharides extracted from <i>Hericium erinaceus.</i>

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Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus.

Content Provider	Europe PMC
Author	LIU, JIANQING DU, CONGXIN WANG, YIFEI YU, ZHIHUA
Copyright Year	2015
Abstract	Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities. The objective of this study was to evaluate the anti-fatigue activity of HEP in a mouse model. After one week of acclimation, mice were randomly divided into four groups: a control group, a low-dose HEP-treated group, a moderate-dose HEP-treated group, and a high-dose HEP-treated group. The treated groups received HEP (50, 100 and 200 mg/kg, ig), while the control group received saline solution. Following treatment for 28 days, the mice performed a forced swimming test until they were exhausted, then the exhaustive swimming time was recorded along with certain biochemical parameters related to fatigue, including blood lactic acid (BLA), serum urea nitrogen (SUN), tissue glycogen, superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). These results suggested that HEP has significant anti-fatigue activity by decreasing BLA, SUN and MDA content, as well as increasing tissue glycogen content and antioxidant enzyme activity. Based on these results, this study provided theoretical support for the application of HEP in the field of sports nutrition.
ISSN	17920981
Journal	Experimental and Therapeutic Medicine
Volume Number	9
PubMed Central reference number	PMC4280918
Issue Number	2
PubMed reference number	25574220
e-ISSN	17921015
DOI	10.3892/etm.2014.2139
Language	English
Publisher	D.A. Spandidos
Publisher Date	2014-12-16
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2015, Spandidos Publications
Subject Keyword	forced swimming test blood lactic acid serum urea nitrogen glycogen superoxide dismutase glutathione peroxidase malondialdehyde mice
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Cancer Research

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