NDLI: Pivotal role of pervasive neoplastic and stromal cells reprogramming in circulating tumor cells dissemination and metastatic colonization.

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Pivotal role of pervasive neoplastic and stromal cells reprogramming in circulating tumor cells dissemination and metastatic colonization.

Content Provider	Europe PMC
Author	Meseure, Didier Drak Alsibai, Kinan Nicolas, Andre
Abstract	Reciprocal interactions between neoplastic cells and their microenvironment are crucial events in carcinogenesis and tumor progression. Pervasive stromal reprogramming and remodeling that transform a normal to a tumorigenic microenvironment modify numerous stromal cells functions, status redox, oxidative stress, pH, ECM stiffness and energy metabolism. These environmental factors allow selection of more aggressive cancer cells that develop important adaptive strategies. Subpopulations of cancer cells acquire new properties associating plasticity, stem-like phenotype, unfolded protein response, metabolic reprogramming and autophagy, production of exosomes, survival to anoikis, invasion, immunosuppression and therapeutic resistance. Moreover, by inducing vascular transdifferentiation of cancer cells and recruiting endothelial cells and pericytes, the tumorigenic microenvironment induces development of tumor-associated vessels that allow invasive cells to gain access to the tumor vessels and to intravasate. Circulating cancer cells can survive in the blood stream by interacting with the intravascular microenvironment, extravasate through the microvasculature and interact with the metastatic microenvironment of target organs. In this review, we will focus on many recent paradigms involved in the field of tumor progression.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4275542&blobtype=pdf
ISSN	18752292
Volume Number	7
DOI	10.1007/s12307-014-0158-2
PubMed Central reference number	PMC4275542
Issue Number	3
PubMed reference number	25523234
Journal	Cancer Microenvironment [Cancer Microenviron]
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-12-19
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	© Springer Science+Business Media Dordrecht 2014
Subject Keyword	Microenvironment Stromal reprogramming ECM remodeling CTCs EMT Invasion Intravasation MET Dormancy Metastasis Tumor self-seeding
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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