NDLI: Dose-dependent protective effect of L-carnitine on oxidative stress in the livers of hyperthyroid rats.

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Dose-dependent protective effect of L-carnitine on oxidative stress in the livers of hyperthyroid rats.

Content Provider	Europe PMC
Author	Yildirim, Serap Yildirim, Abdulkadir Dane, Senol Aliyev, Elvin Yigitoglu, Ramazan
Copyright Year	2013
Abstract	Objective: The present study was designed to investigate the dose-dependent protective effect of L-carnitine (LC) on thyroid hormone-induced oxidative stress in rat liver tissue. Materials and Methods: Twenty-one male Sprague Dawley rats were divided into four groups: control, hyperthyroidism, hyperthyroidism plus L-carnitine 100, and hyperthyroidism plus L-carnitine 500. Hyperthyroidism was induced in rats by injecting 250 μg of L-thyroxine/kg body weight/day for twenty consecutive days. The activities of catalase (CAT), glutathione peroxidase (GPX) and myeloperoxidase (MPO) and the level of malondialdehyde (MDA) were measured in liver homogenates. Results: The liver CAT, GPX and MPO activities were significantly lower in the hyperthyroid rats than in the control group. Treating hyperthyroid rats with both low-dose (100 mg/kg) and high-dose (500 mg/kg) L-carnitine for 10 days resulted in a marked increase in the activities of the antioxidant enzymes in the liver tissue. Conclusion: The present study indicates that the low-dose L-carnitine application was sufficient to prevent L-thyroxine-induced oxidative stress in rat livers.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4261500&blobtype=pdf
ISSN	13088734
Volume Number	45
DOI	10.5152/eajm.2013.01
PubMed Central reference number	PMC4261500
Issue Number	1
PubMed reference number	25610241
Journal	The Eurasian Journal of Medicine [Eurasian J Med]
e-ISSN	13088742
Language	English
Publisher	Atatürk University School of Medicine
Publisher Date	2013-02-01
Access Restriction	Open
Rights License	© Copyright 2013 by the Atatürk University School of Medicine
Subject Keyword	Catalase glutathione peroxidase L-carnitine Liver Malondialdehyde Myeloperoxidase
Content Type	Text
Resource Type	Article
Subject	Medicine

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