NDLI: Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.

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Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.

Content Provider	Europe PMC
Author	WANG, MIN ZHU, JING-YU CHEN, SHUO QING, YING WU, DONG LIN, YING-MIN LUO, JI-ZHUANG HAN, WEI LI, YAN-QING
Copyright Year	2014
Abstract	Sulforaphane (SFN), which is highly enriched in cruciferous vegetables, has been investigated for its cancer chemopreventive properties and ability to induce autophagy. Uridine 5′-diphospho (UDP)-glucuronosyltransferase (UGT)1A induction is one of the mechanisms that is responsible for the cancer chemopreventive activity of SFN. The current study demonstrates that rapamycin may enhance the chemopreventive effects of SFN on Caco-2 cells; this may be partially attributed to nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2)- and human pregnane X receptor (hPXR)-mediated UGT1A1, UGT1A8 and UGT1A10 induction. These results indicate that targeting autophagy modulation may be a promising strategy for increasing the chemopreventive effects of SFN in cases of colon cancer.
ISSN	17921074
Journal	Oncology Letters
Volume Number	8
PubMed Central reference number	PMC4214451
Issue Number	6
PubMed reference number	25364403
e-ISSN	17921082
DOI	10.3892/ol.2014.2536
Language	English
Publisher	D.A. Spandidos
Publisher Date	2014-09-15
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2014, Spandidos Publications
Subject Keyword	uridine 5′-diphospho-glucuronosyltransferase 1A Caco-2 cells sulforaphane chemoprevention cytochrome P450 3A4 autophagy
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5′-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells

Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5′-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells

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