NDLI: Comparative Study on the EC50 Value in Single and Mixtures of Dimethylformamide, Methyl Ethyl Ketone, and Toluene.

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Comparative Study on the EC50 Value in Single and Mixtures of Dimethylformamide, Methyl Ethyl Ketone, and Toluene.

Content Provider	Europe PMC
Author	Kim, Ki-Woong Won, Yong Lim Park, Dong Jin Kim, Doh-Hee Song, Kwan Young
Copyright Year	2014
Abstract	The aim of this research was to improve our understanding of human toxicity due to exposure to DMF, MEK, or TOL individually as compared to exposure to DMF-MEK or DMF-TOL mixtures, by comparing EC50 values as well as the morphological changes in HepG2 cells treated with these substances. We found that there was marked cell necrosis in the groups treated with mixtures than in those treated with the compounds alone, and that the amount of cell death and the EC50 value were more dependent on MEK and TOL than on DMF. Moreover, analysis of the changes in effective concentration curves revealed that MEK had an antagonistic effect on the human toxicity of DMF, whereas TOL had a synergistic effect. Accordingly, these results suggest that in workplaces involved in the manufacture of synthetic leather, mixtures of DMF and TOL should be avoided as much as possible in order to minimize environmental toxicity and protect the health of the workers.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4206747&blobtype=pdf
ISSN	19768257
Journal	Toxicological Research [Toxicol Res]
Volume Number	30
PubMed Central reference number	PMC4206747
Issue Number	3
PubMed reference number	25343014
e-ISSN	22342753
DOI	10.5487/tr.2014.30.3.199
Language	English
Publisher	The Korean Society Of Toxicology
Publisher Date	2014-09-01
Access Restriction	Open
Rights License	This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2014, The Korean Society Of Toxicology
Subject Keyword	Dimethylformamide Methy ethyl ketone Toluene Mixtures EC50
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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